Topic description and stories

Brain showing hallmarks of Alzheimer’s disease (plaques in blue)

Computer-designed antibodies target toxins associated with Alzheimer’s disease

22 Jun 2017

Researchers at the University of Cambridge have designed antibodies that target the protein deposits in the brain associated with Alzheimer’s disease...

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Scientists discover two repurposed drugs that arrest neurodegeneration in mice

20 Apr 2017

A team of scientists who a few years ago identified a major pathway that leads to brain cell death in mice, have now found two drugs that block the...

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Cambridge named as a centre for the UK Dementia Research Institute

20 Apr 2017

The University of Cambridge has been announced as one of the centres that will form the UK Dementia Research Institute (UK DRI) alongside Cardiff...

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Hands

Public attitudes towards end-of-life care in progressive neurological illness are conflicted, study reveals

05 Apr 2017

Public attitudes in UK and USA reveal support both for life-sustaining interventions and for measures to enable peaceful death in progressive...

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Dementia: Catching the memory thief

21 Sep 2016

It's over a hundred years since the first case of Alzheimer’s disease was diagnosed. Since then we’ve learned a great deal about the protein ‘tangles...

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In healthy tissues, a gene expression signature associated with amyloid-beta and tau aggregation echoes the progression of AD well before the onset of the disease.

Gene signature in healthy brains pinpoints the origins of Alzheimer’s disease

10 Aug 2016

A specific gene expression pattern maps out which parts of the brain are most vulnerable to Alzheimer’s disease, decades before symptoms appear, and...

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New cases of dementia in the UK fall by 20% over two decades

19 Apr 2016

The UK has seen a 20% fall in the incidence of dementia over the past two decades, according to new research from England, led by the University of...

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Fibrils of amyloid-beta

Researchers identify ‘neurostatin’ that may reduce the risk of Alzheimer’s disease

12 Feb 2016

An approved anti-cancer drug successfully targets the first step in the toxic chain reaction that leads to Alzheimer’s disease, suggesting that...

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Jello Cubes

Breaking the mould: Untangling the jelly-like properties of diseased proteins

29 Oct 2015

Scientists at the University of Cambridge have identified a new property of essential proteins which, when it malfunctions, can cause the build up...

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“It ought to be lovely to be old, To be full of the peace that comes with experience And wrinkled ripe fulfillment” D.H. Lawrence

Despite the headlines, dementia epidemic may not actually be getting worse

21 Aug 2015

The number of people with dementia – both new cases and total numbers with the disease – appears to be stabilising in some Western European countries...

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Brain coral

Study suggests new treatment for impulsivity in some dementia patients

25 Jun 2015

Restoring the low levels of the chemical serotonin may help improve brain function and reduce impulsivity in some dementia patients, according to...

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Elderly hands

Cambridge Drug Discovery Institute to fast-track development of new treatments for dementia

16 Feb 2015

Alzheimer’s Research UK, the world’s largest dedicated dementia research charity, has announced a £30 million Drug Discovery Alliance, launching...

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