Articles about 'David Rubinsztein'

Cambridge scientists have shown how the brain’s ability to clear out toxic proteins is impaired in Huntington’s disease and other forms of dementia – and how, in a study in mice, a repurposed HIV drug was able to restore this function, helping prevent this dangerous build-up and slowing progression of the disease.

A prescription drug to treat high blood pressure has shown promise against conditions such as Parkinson’s, Huntington’s and forms of dementia in studies carried out in mice and zebrafish at the University of Cambridge.

Seven Cambridge academics are among the new Fellows announced today by the Royal Society. Fellows are chosen for their outstanding contributions to science. The 50 newly-elected Fellows announced today join a list of scientists, engineers and technologists from the UK and Commonwealth. Past Fellows and Foreign Members have included Newton, Darwin and Einstein.

Yoshinori Ohsumi is a deserving winner of this year's Nobel Prize in physiology or medicine, whose work shows the value of basic research, writes Professor David Rubinsztein, Deputy Director of the Cambridge Institute for Medical Research on The Conversation website.

It's over a hundred years since the first case of Alzheimer’s disease was diagnosed. Since then we’ve learned a great deal about the protein ‘tangles’ and ‘plaques’ that cause the disease. How close are we to having effective treatments – and could we even prevent dementia from occurring in the first place?

Alzheimer’s Research UK, the world’s largest dedicated dementia research charity, has announced a £30 million Drug Discovery Alliance, launching three flagship Drug Discovery Institutes at the Universities of Cambridge, Oxford and UCL (University College London). The Drug Discovery Institutes will see 90 new research scientists employed in state-of-the-art facilities to fast-track the development of new treatments for Alzheimer’s disease and other dementias.

New research from scientists at the University of Cambridge provides critical insight into the formation of autophagosomes, which are responsible for cleaning up cellular waste.