Journeys of discovery: Azim Surani on the earliest stages of life
24 October 2024Azim Surani has followed his curiosity for over half a century, rewriting science in the process.
Azim Surani has followed his curiosity for over half a century, rewriting science in the process.
We’re used to the idea that as adults we have some control over our destiny: what we eat and drink and how much we exercise can affect our health. But the risks of heart disease and diabetes can be programmed much earlier – even before we are born.
Scientists have shown how the precursors of egg and sperm cells – the cells that are key to the preservation of a species – arise in the early embryo by studying pig embryos alongside human stem cells.
Azim Surani (Wellcome Trust/Cancer Research UK Gurdon Institute) discusses gene editing of the human germline.
A team of researchers led by the University of Cambridge has described for the first time in humans how the epigenome – the suite of molecules attached to our DNA that switch our genes on and off – is comprehensively erased in early primordial germ cells prior to the generation of egg and sperm.
Scientists at the University of Cambridge working with the Weizmann Institute have created primordial germ cells – cells that will go on to become egg and sperm – using human embryonic stem cells. Although this had already been done using rodent stem cells, the study, published today in the journal Cell, is the first time this has been achieved efficiently using human stem cells.
The Indian Prime Minister, Dr Manmohan Singh, announced at the 101st Annual Session of the Indian Science Congress that Professor Azim Surani of the Gurdon Institute has been awarded the prestigious Jawaharlal Nehru Fellowship by the Government of India’s Department of Science and Technology.
Professor Azim Surani of the Cambridge Stem Cell Institute has been granted the 2014 McEwen Award for Innovation by the International Society for Stem Cell Research (ISSCR).
Research reveals the mechanism of epigenetic reprogramming.
In the first report of our Egg Cetera series on egg-related research, biologists Dr Harry Leitch and Professor Azim Surani describe how advances in understanding egg development could transform reproductive and regenerative medicine.